Acetyl hexapeptide-8 (CAS: 616204-22-9) is a revolutionary anti-wrinkle product. Acetyl hexapeptide-8 has been used in the high-end cosmetics of the world as an anti-wrinkle active ingredient. It is a raw material polypeptide obtained by scientific understanding of the molecular biology mechanism of wrinkle formation and reasonable design. It has become a popular anti-wrinkle active ingredient in the world. Compared with botulinum toxin A, it is not only safer, but also avoids the shortcomings of botulinum toxin injection.
One of the most striking signs of aging is the increase in facial wrinkles. This occurs naturally over time due to changes in biochemistry, histology and physiology, and environmental enhancement. In addition, there are many secondary factors leading to increased wrinkles and lines on the skin. For example, Continuous Gravitational pull, constant and long-term pressure on the facial skin, as well as repeated facial movements such as the influence of facial muscles. In either case, the molecular mechanism of facial aging is associated with changes in three-dimensional conformation of collagen, degradation of elastin and disorders of subcutaneous fat.
It is now clear that these conformational changes, protein degradation and disorders of subcutaneous fat can be avoided by reducing muscle pull.
Muscle contraction depends on the release of vesicle neurotransmitters in nerve cells. SNARE complex is a necessary condition for the release of neurotransmitters at synapses. It is a ternary complex composed of VAMP, Syntaxin and SNAP-25. This complex acts like a molecular hook that grabs the vesicle and fuses it with the protruding anterior membrane, leading to the release of neurotransmitters.
Figure 1. Mechanisms of action of acetyl hexapeptide-8
Acetyl hexapeptide-8 mimics the nitrogen terminal of SNAP-25 protein, which can compete for the position of SNAP-25 in the SNARE complex and make it unable to form. If the SNARE complex loses its stability slightly, the vesicles cannot effectively release neurotransmitters, and the muscles cannot contract accordingly, thus preventing wrinkles from forming.
Characteristics and Application
Acetyl hexapeptide-8 is used to alleviate facial wrinkles caused by continuous stretching of facial expression muscles.
Acetyl hexapeptide-8 is a safe, cheap and mild substitute for botulinum toxin, and achieves the same effect through a different mechanism.
Acetyl six peptide -8 can be added to various cosmetic formulations, such as emulsion, gel, serum and so on. It is especially effective for wrinkles around the forehead and eyes.
|Appearance||White to off white powder||White powder|
|Water Content (K.F.)||≤8%||5.4%|
|Acetate Content (HPLC)||≤8%||5.7%|
|TFA Content (HPIC)||<2%||0.7%|
|Peptide Content (by %N )||≥80.0%||81.3%|